Further studies are needed in other populations.Īlcohol consumption Knee osteoarthritis Prospective cohort Risk.Ĭopyright © 2022 Osteoarthritis Research Society International. Our results suggest that excessive alcohol drinking was associated with an increased risk of knee OA. Light to moderate alcohol consumption was not associated with knee OA risk. Similar association was observed for liquor consumption (HR liquor≥15 g/d vs none = 1.71, 95% CI: 1.16-2.52 for ROA HR liquor≥15 g/d vs none = 1.59, 95% CI: 1.04-2.39 for SxOA). Compared to non-drinkers, excessive alcohol consumption was significantly associated with increased risk of ROA (HR ≥ 30 g/d vs none = 1.93, 95% CI: 1.28-2.89) and SxOA (HR ≥ 30 g/d vs none = 1.61, 95% CI: 1.04-2.48). The Cox proportional hazards models were used to assess the independent association between alcohol consumption and risk of knee.ĭuring 96 months' follow-up, we identified 691 knees with incident ROA, and 496 knees with incident SxOA among 2,846 subjects. Incident symptomatic OA (SxOA) was defined as ROA with knee pain worsening. Incident cases of radiographic knee OA (ROA) were defined as Kellgren-Lawrence grade changing from zero or one to ≥ two during the follow-up time. Information on baseline alcohol consumption was obtained from the Block Brief Food Frequency Questionnaire. In the Osteoarthritis Initiative, 2,846 participants aged 45-79 years and free from radiographic knee OA in at least one knee at baseline were followed up to 96 months. Electronic address: examine the association of alcohol consumption with risk of incident knee osteoarthritis (OA) in a large prospective cohort study. 5 Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA Department of Public Health Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.
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